The group of researchers from Brown University Medical School
analyzed, in the frontal part of the brain, one of the major
area affected by Alzheimer's, insulin and insulin receptor
function.
The team discovered that the levels of insulin receptors and the
brain's ability to respond to insulin decreased as the severity
of Alzheimer's increased.
According to the experts, insulin receptors were nearly 80
percent lower than in a normal brain in the most advanced stage
of Alzheimer's.
Two abnormal situations related to insulin in Alzheimer's were
also found by researchers. The first abnormal situation was that
as the disease progressed, levels of insulin dropped. In
relation to the second one, experts explained that insulin and
its related protein, insulin-related growth factor-I, lose the
ability to bind to cell receptors, which creates a resistance to
the insulin growth factors, causing the cells to malfunction and
die.
For the neuropathologist at Rhode Island Hospital and professor
of pathology at Brown University Medical School, Suzanne M. de
la Monte, this means that they are able to show that insulin
impairment happens early in the disease, as well as they are
able to show it is linked to major neurotransmitters responsible
for cognition.
"We're able to show it's linked to poor energy metabolism, and
it's linked to abnormalities that contribute to the tangles
characteristic of advanced Alzheimer's disease. This work ties
several concepts together and demonstrates that Alzheimer's
disease is quite possibly a Type 3 diabetes", explains de la
Monte, the leader of the research.
Article written by Hector Milla editor of
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Article written by Hector Milla editor of
http://www.mydiabetessuppl
y.com, a website about
diabetes testing
supply, or you may read their last article ::
Information on Diabetes High Blood Sugar
Symptoms :: at
